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IHS Diagnosis ICD-10
13.17 Ophthalmoplegic “migraine” G43.80  

Description:

Recurrent attacks of headache with migrainous characteristics associated with paresis of one or more ocular cranial nerves (commonly the third nerve) in the absence of any demonstrable intracranial lesion other than MRI changes within the affected nerve.

Diagnostic criteria:

  1. At least 2 attacks fulfilling criterion B
  2. Migraine-like headache accompanied or followed within 4 days of its onset by paresis of one or more of the third, fourth and/or sixth cranial nerves
  3. Parasellar, orbital fissure and posterior fossa lesions ruled out by appropriate investigations

Comment:

This condition is very rare. It is unlikely that 13.17 Ophthalmoplegic "migraine" is a variant of migraine since the headache often lasts for a week or more and there is a latent period of up to 4 days from the onset of headache to the onset of ophthalmoplegia. Furthermore, in some cases MRI shows gadolinium uptake in the cisternal part of the affected cranial nerve which suggests that the condition may be a recurrent demyelinating neuropathy.

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