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IHS Diagnosis ICD-10
7.3.4 Headache attributed to lymphocytic hypophysitis [E23.6] G44.82  

Diagnostic criteria:

  1. Headache, no typical characteristics known, fulfilling criterion C
  2. Hypopituitarism fulfilling the following criteria:
    1. MRI demonstrates symmetrical pituitary enlargement with homogeneous contrast-enhancement
    2. biopsy confirmation of lymphocytic hypophysitis
  3. Headache develops in close temporal relation to hypopituitarism

Comments:

Lymphocytic hypophysitis is often accompanied by hyperprolactinaemia (50% of cases) or autoantibodies against hypophyseal cytosol protein (20%).

This disorder typically develops at the end of pregnancy or during the post-partum period, but it can occur in men.

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